potassium thiocyanate toxicity

Oxidation of N-arylthioureas (261) with acidic hydrogen peroxide produces ‘Hector’s bases’ (73) which readily isomerize under basic conditions to afford 3,5-diamino-1,2,4-thiadiazoles (84; Scheme 146) 〈65AHC(5)119〉 (also see Scheme 92). Potassium thiocyanate CAS 333-20-0 EMPLURA® - Find MSDS or SDS, a COA, data sheets and more information. Potassium Thiocyanate (333 -20 -0) LD50 oral rat 854 mg/kg On post-mortem congestion of the stomach and intestine, hemorrhagic suffusions and petechiae along the GIT and occasionally on the surface of bladder have been observed. Potassium compound "What do you need help with?" Another fungicide, barium polysulfide, after reaction with gastric acid yields barium chloride, which is a super purgative (Lorgue et al., 1996; Ballantyne, 2003; Sandhu and Brar, 2009). The compound has a low melting point relative to most other inorganic salts. Ecological Information Environmental Fate: No information found. Thus the complete absence of thiocyanate or reduced thiocyanate in the human body, (e.g., cystic fibrosis) is damaging to the human host defense system. o-Nitrochlorobenzene (539) reacts with the sodium salt of α-mercaptoacetic acid affording o-nitrophenylthioacetic acid (540) which, in the presence of acetic anhydride and further treatment with base or acid, gives the 2-hydroxybenzothiazole (541; Scheme 290). Potassium Thiocyanate, 0.1M Created by Global Safety Management, Inc. -Tel: 1-813-435-5161 - www.gsmsds.com CAS 333-20-0 Potassium Thiocyanate, ACS 0.9718 % CAS 7732-18-5 Deionized Water 99.028 % Percentages are by weight SECTION 4 : First aid measures Description of first aid measures After inhalation: Remove to fresh air. COVID-19 is an emerging, rapidly evolving situation. Potassium Thiocyanate is the chemical compound with the molecular formula KSCN. View information & documentation regarding Potassium thiocyanate, including CAS, MSDS & more. We use cookies to help provide and enhance our service and tailor content and ads. Potassium thiocyanate 333-20-0 100 Toxicological Data on Ingredients: Potassium thiocyanate: ORAL (LD50): Acute: 854 mg/kg [Rat]. In ruminants, excessive sulfur ingestion may lead to polioencephalomalacia, which is also called cerebrocortical necrosis. ... Potassium thiocyanate. ... Oral/Parenteral Toxicity: intravenous-dog LDLo 100 mg/kg Journal of the American Pharmaceutical Association, Scientific Edition. Toxicity: 2 Body Contact: 2 Reactivity: 0 Chronic: 2 Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4 NAME CAS RN % potassium thiocyanate 333-20-0 > 97 Section 4 - FIRST AID MEASURES SWALLOWED IF SWALLOWED, REFER FOR MEDICAL ATTENTION, WHERE POSSIBLE, WITHOUT DELAY. It is an important salt of the thiocyanate anion, one of the pseudohalides. Now, its use has declined due to availability of organic fungicides. Sigma-Aldrich offers a number of Potassium thiocyanate solution products. Running and blurring of the image can result from spraying too strongly. Potassium thiocyanate. Barium polysulfide after reaction with gastric acid yields barium chloride which is super purgative (Lorgue et al., 1996; Sandhu and Brar, 2000; Ballantyne, 2004). Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children. The reaction of 3-bromo-3-methylbutan-2-one with hydrazine and potassium thiocyanate in acetic acid affords the mesoionic compound (8) (Equation (128)) 〈93TH 805-01, 95FES379〉. A variety of 3-amino-and 3,5-diamino-1,2,4-thiadiazoles (325) also have been obtained by the treatment of iminocarbonates (322) with chloramine at low temperature, as illustrated in Scheme 147 (also see Scheme 115) 〈76EGP119791〉. 13. Toxicity * denotes mobile formatted website. Thiocyanic acid, potassium salt. Vol. Potassium Thiocyanate 1. Welcome to PubChem! Sigma-Aldrich offers a number of Potassium thiocyanate solution products. Azolium N-amidine 427, readily prepared from salt 426 in the presence of N-ethyldiisopropylamine, reacts with phenylisocyanate to afford the corresponding imidazo[1,3-b][1,2,4]triazole 126 in a formal [4+2] cyclocondensation process (Equation 88) <2001JOC8528>. To view acute toxicity of individual products, click on 'View Products' link in the 'Chemical Identification' section above. Organic compounds containing the functional group SCN are also called thiocyanates. MDL number MFCD00011413. EC number: 206-370-1 | CAS number: 333-20-0 . Potassium thiocyanate - Identification, toxicity, use, water pollution potential, ecological toxicity and regulatory information Note : See Working with the Information on this Page section below for important notes about this data. POTASSIUM SALT THIOCYANIC ACID, POTASSIUM THIOCYANATE, and THIOCYANIC ACID, POTASSIUM SALT. The image can be built up by repeated sprayings. D.O. Oxidation at the sulfur of the safe-to-handle potassium thiocyanate releases cyanide units that are trapped in the presence of co-oxidized tertiary amines to form α-amino nitriles. Presented before the Scientific Section, A. Ph . This class of fungicides includes potassium azide, potassium thiocyanate and titrated or sublimed sulfur. Tymoshenko, in Comprehensive Heterocyclic Chemistry III, 2008. Potassium Thiocyanate 1. Copyright © 2021 Elsevier B.V. or its licensors or contributors. Key intermediate 77b was prepared from 76 in one step under acidic catalysis. potassium thiocyanate Potassium thiocyanate 2.6 mg/m3 28 mg/m3 170 mg/m3 Ingredient Original IDLH Revised IDLH potassium thiocyanate Not Available Not Available Exposure controls Appropriate engineering controls Engineering controls are used to remove a hazard or place a barrier between the worker and the hazard. EC number: 206-370-1 | CAS number: 333-20-0 . No intermediate acyl chloride was observed during the cyclization of 77a, and product 78 (X = O) was isolated in low 15% yield. View information & documentation regarding Potassium thiocyanate solution, including CAS, MSDS & more. Potassium thiocyanate. Chemical Product and Company information. 333-20-0. 29, Pg. Hazard Identification Hazardous in case of skin contact (irritant, permeator), of eye contact (irritant), of ingestion, of inhalation (lung Pesticide properties for Potassium thiocyanate, including approvals, environmental fate, eco-toxicity and human health issues Potassium Thiocyanate, 0.1M Created by Global Safety Management, Inc. -Tel: 1-813-435-5161 - www.gsmsds.com CAS 333-20-0 Potassium Thiocyanate, ACS 0.9718 % CAS 7732-18-5 Deionized Water 99.028 % Percentages are by weight SECTION 4 : First aid measures Description of first aid measures After inhalation: Remove to fresh air. S-Acyl-o-aminothiophenols (537), generally formed by the reduction of S-acyl-o-nitrothiophenols (536) readily undergo cyclization to 2-hydroxybenzothiazoles (538; Scheme 289). Disposal Considerations Whatever cannot be saved for recovery or recycling should be managed … The elimination half-life of cyanide is 2-3 hours This class of fungicides includes potassium azide, Jensen et al., 1956; Low et al., 1996; Gammon et al., 2010, Bicyclic 5-5 and 5-6 Fused Ring Systems with at least One Bridgehead (Ring Junction) N, J. Marco-Contelles, ... P. Ballesteros, in, Six-membered Rings with Two or More Heteroatoms and Fused Carbocyclic Derivatives, Fused Five- and Six-membered Rings with Ring Junction Heteroatoms, The reaction of 3-bromo-3-methylbutan-2-one with hydrazine and, Eight-membered and larger Heterocyclic Rings and their Fused Derivatives, Other Seven-membered Rings, -phenyl(phenylimino)methylchloromethanimidoyl chloride with secondary amines and. 2 . Similarly, 2,3-dihydro-1H-pyrrolo[1,2-e][1,3,5]thiadiazocin-6(5H)-one ring system 19 (X = S) was obtained in low yield. EC Number 206-370-1. Thiocyanate | SCN(−) or CNS- | CID 9322 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Sigma-Aldrich offers a number of Potassium thiocyanate products. Since Westphal 1 in 1925 reintroduced the use of potassium thiocyanate for the treatment of hypertension, varying and conflicting reports have appeared in the literature concerning the merits of this treatment. Environmental Toxicity: No information found. 594 mg/kg [Mouse]. On postmortem, congestion of the stomach and intestine, hemorrhagic effusions and petechiae along the GI tract and occasionally on the surface of the bladder have been observed (Jensen et al., 1956; Low et al., 1996; Gammon et al., 2010). High purity, submicron and nanopowder forms may be considered. Potassium thiocyanate (>= 80 % - <= 100 % ) 333-20-0 01-2119543697-26-XXXX Acute toxicity, Category 4, H302 Acute toxicity, Category 4, H332 Acute toxicity, Category 4, H312 Serious eye damage, Category 1, H318 Long-term (chronic) aquatic hazard, Category 3, H412 Thiocyanate is known to be an important part in the biosynthesis of hypothiocyanite by a lactoperoxidase. Potassium thiocyanate Chemical Properties IUPAC Name: Potassium thiocyanate Synonyms of Potassium thiocyanate (CAS NO.333-20-0): Arterocyn ; Kyonate ; Potassium isothiocyanate ; Potassium thiocyanate ; Thiocyanic acid, potassium salt (1:1) The image should be photographed using a #58 or #61 green filter. Sulfur poisoning may lead to GI tract, neurological and pulmonary effects. Treatment of N,N-dimethylthiocarbamoyl chloride (214) with potassium thiocyanate affords the 6-dimethylamino-1,3,5-thiadiazine-2-thione derivative (215; Scheme 34), the structure of which has been confirmed by x-ray analysis (see Section 6.18.3.1.3) 〈89IZV909〉. 13. Persistence and degradability Potassium Thiocyanate, 0.1N (0.1M) Persistence and degradability Not established. We use cookies to help provide and enhance our service and tailor content and ads. Potassium Thiocyanate,ACS Created by Global Safety Management, 1-813-435-5161 - www.GSMSDS.com Incompatible materials: Strong acids, Strong bases. Synthesis. potassium thiocyanate 854 (oral, rats) a According to the Globally Harmonized System of Classification and Labeling of Chemicals (GHS Classification) compounds with LD50 < 300 mg kg–1 are classified as toxic (data from MSDS sheets by Sigma-Aldrich, Steinheim, Germany, Dec. 12th, 2014). Shelf life is probably several months, but it is advisable to make it up freshly. 77, No. Sulfur had been in use in the 19th and early 20th century. Journal of the American Pharmaceutical Association (Scientific ed. The most affected animals are cattle, sheep, goats and dogs. LabBot. Acute toxicity (dermal), Category 4 H312 Acute toxicity (inhal. Dhingra, in Comprehensive Heterocyclic Chemistry, 1984. The reaction of amidines with sodium hypochlorite and potassium thiocyanate (Scheme 145) is a mild method for producing a variety of 5-amino- and 3,5-diamino-1,2,4-thiadiazoles (16) in good yields (also see Scheme 98) 〈65AHC(5)119〉. 2 . Reaction of 3-bromo-3-methylbutan-2-one with triphenylmethylhydrazine and potassium thio-cyanate in acetic acid gives 7,7,7a-trimethyl-2,3,5,6,7,7a-hexahydro-1H-imidazo[1,5-b][1,2,4]-triazole-2,5-dithione (381b) due to the facile hydrolysis the triphenylmethyl group. Among the compounds bearing an SC group are the thiocyanates, the S-acylthiophenols and the arylthioesters. Imidoyl isothiocyanates 74 are readily available through stepwise nucleophilic substitution of N-phenyl(phenylimino)methylchloromethanimidoyl chloride with secondary amines and potassium thiocyanate. Molecular Weight 97.18 . Toxicity * denotes mobile formatted website. 4 (Oral) Acute toxicity (oral), Category 4 Aquatic Chronic 3 Hazardous to the aquatic environment — Chronic Hazard, Category 3 H302 Harmful if swallowed Potassium cyanide is a compound with the formula K CN.This colorless crystalline salt, similar in appearance to sugar, is highly soluble in water. Potassium Thiocyanate (333-20-0) No No None 12. 58 / Monday, March 26, 2012 / Rules and Regulations 02/14/2018 EN (English US) 5/6 Likely routes of exposure : Skin and eye contact; Inhalation Acute toxicity : Oral: Harmful if swallowed. Stephen P. Kasper, in Latent Print Processing Guide, 2016. Potassium thiocyanate; Potassium thiocyanate. N-substituted derivatives are obtained when isothiocyanates (RCNS) are used in place of potassium thiocyanate 〈78USP4107377〉. Reproductive toxicity No data available 11.4 Toxicological information Potassium Thiocyanate Oral Rat LD50 (mg/kg): 854 Section 12: Ecological information 12.1 Toxicity: Toxicity to daphnia and other aquatic vertebrates Potassium Thiocyanate EC50 Daphnia magna (Water flea) (mg/l - 48hr): 11 Section 13: Disposal considerations Subsequent thermal intramolecular cyclization of intermediates 74 affords substituted 1,3,5-benzotriazocine derivatives 75 (Equation 8; <2005ARK96>). Joachim G. Schantl, in Comprehensive Heterocyclic Chemistry II, 1996. In a reaction similar to that described for the preparation of 1,3,5-oxadiazinium salts (209) (Scheme 32; see Section 6.18.10.3.1.i) methyl thiocyanate in the presence of SbCl5 undergoes cyclocondensations with arylthiocarbonyl chlorides to give 2-aryl-4,6-bis(methylthio)-1,3,5-thiadiazinium hexachloroantimonates (221) (39–46%) 〈88LA729〉. Lethal doses are as follows: cattle, 100–1000 mg/kg body weight (BW); sheep, 1000–1500 mg/kg BW; and horses, 1000–1500 mg/kg BW. SCN interferes with active uptake and concentration of inorganic iodide by the thyroid and inhibits the enzyme thyroperoxidase thereby preventing the incorporation of iodine into thyroglobulin. Pesticide properties for Potassium thiocyanate, including approvals, environmental fate, eco-toxicity and human health issues 12.1 Toxicity Toxicity to fish LC50 - Oncorhynchus mykiss (r ainbow trout) - > 100 mg/l - 96,0 h Toxicity to daphnia and EC50 - Daphnia magna (W ater flea) - 11 mg/l - 48 h other aquatic invertebrates 12.2 Persistence and degradability No data available 12.3 Bioaccumulative potential Bioaccumulation Oncorhynchus mykiss (r ainbow trout) - 16 Weeks EC number: 206-370-1 | CAS number: 333-20-0 . A PPRTV is defined as a toxicity value derived for use in the Superfund Program when ... the following thiocyanates: sodium thiocyanate (CASRN 540-72-7), potassium thiocyanate . Toxicity Potassium Thiocyanate (333-20-0) LC50 fish 1 > 100 mg/l EC50 Daphnia 1 11 mg/l 12.2. Several of these trials involved intranasal administration in an attempt to stimulate mucosal immunity and inhibit bacterial colonization. Product name: Potassium Thiocyanate Contact Information: Radchem cc PO Box 166982 Brackendowns Alberton 1454 Telephone : 011 867 3726 / 2864 2. Hexafluorothiopropanone, generated in situ from the stable 2,2,4,4-tetrakis(trifluoromethyl)-1,3-dithietane (219), reacts in an analogous manner to that described for hexafluoropropanone (Scheme 31; see Section 6.18.10.3.1.i) with an excess of dialkyl cyanamides to give 2,6-bis(dialkylamino)-4,4-bis(trifluoromethyl)-4H-1,3,5-thiadiazines (220) (Scheme 36) 〈84LA982〉. Ecological Information Environmental Fate: No information found. 152, 1940. intramuscular-frog LDLo 100 mg/kg Elemental sulfur and crude lime sulfur (calcium polysulfide and barium polysulfide) are commonly used as fungicides. Regulation. Chemical Product and Company information. Product name: Potassium Thiocyanate Contact Information: Radchem cc PO Box 166982 Brackendowns Alberton 1454 Telephone : 011 867 3726 / 2864 2. Persistence and degradability Potassium Thiocyanate, 4% w/ v … Potassium thiocyanate - Identification, toxicity, use, water pollution potential, ecological toxicity and regulatory information Note : See Working with the Information on this Page section below for important notes about this data. Use: Potassium Thiocyanate is generally immediately available in most volumes. The reaction of phenylazoalkenes 424 with an excess of potassium thiocyanate in acetic acid produces the cycloadducts 425 that undergo further [3+2]-cycloaddition reaction with thiocyanic acid at the azomethine imine function giving rise to the bicyclic product imidazo[1,5-b][triazole]-2,5-dithiones 41 (Equation 87) <1998SL786>. This property is responsible for sulfur’s effects on the eyes, skin, and respiratory tract. Apply Potassium Thiocyanate by spraying from an aerosol-powered spray in a fume cupboard (a fine mist or spray produces better detail than a heavy spray). Potassium Thiocyanate Safety Data Sheet according to Federal Register / Vol. This class of fungicides includes potassium azide, potassium thiocyanate, and titrated or sublimed sulfur. ), Category 4 H332 Acute toxicity (oral), Category 4 H302 Hazardous to the aquatic The most affected animals are cattle, sheep, goats, and dogs. This tandem reaction resembles a new variety of the “criss-cross” reaction (with respect to the relative regiochemistry of the added thiocyanic acid this reaction is a “parallel criss-cross” reaction as opposed to the “antiparallel” cycloaddition of heterocumulenes to azines in the classical “criss-cross” reaction). Potassium thiocyanate was used over 50 years ago for the treatment of hypertension and its toxicity appears to cause a neurological disorder consisting of generalized weakness, Published by Elsevier Inc. All rights reserved. Potassium thiosulfate | K2S2O3 or K2O3S2 | CID 61501 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. 594 mg/kg [Mouse]. The use of sulfur does not present a toxicological problem. Several of these trials involved intranasal administration in an attempt to stimulate mucosal immunity and inhibit bacterial colonization. Alternatives. ... Potassium thiocyanate. 3-15-2006 (CASRN 333-20-0), calcium thiocyanate (CASRN 2092-16-2), ammonium thiocyanate (CASRN MSDS MATERIAL SAFETY DATA SHEET CHEMTREC: 800-424-9300 (USA) ----- 703-527-3887(Outside USA and Canada) CANUTEC: 613-996-6666 From: Mallinckrodt Baker, Inc 222 Red School Lane The o-aminoaryl thiocyanates may be prepared directly by the action of thiocyanogen (NCS)2 on arylamines. SECTION 11: Toxicological information Acute Toxicity: Oral: 333 - 20 - 0 LD50 oral - rat : 854mg/kg Potassium Thiocyanate is an inorganic salt. Methyl thiocyanate is expected to volatilize from water surfaces(3,SRC) based on an estimated Henry's Law constant of 4.4X10-5 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Toxicity Potassium Thiocyanate (333 -20 -0) LC50 fish 1 > 100 mg/l EC50 Daphnia 1 11 mg/l 12.2. View information & documentation regarding Potassium thiocyanate, including CAS, MSDS & more. Toxicity: 2 Body Contact: 2 Reactivity: 0 Chronic: 2 Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4 NAME CAS RN % potassium thiocyanate 333-20-0 > 97 Section 4 - FIRST AID MEASURES SWALLOWED IF SWALLOWED, REFER FOR MEDICAL ATTENTION, WHERE POSSIBLE, WITHOUT DELAY. Metzger, in Comprehensive Heterocyclic Chemistry, 1984. Chen, ††Lilly Research Laboratories, Eli Lilly and Company, Indianapolis References (1) W. Pauli, über Ionenwirkungen und ihre therapeutische Verwebndug Münch. Thiocyanate (also known as rhodanide) is the anion [SCN] −.It is the conjugate base of thiocyanic acid.Common derivatives include the colourless salts potassium thiocyanate and sodium thiocyanate. By continuing you agree to the use of cookies. In general, the use of sulfur does not present a toxicological problem. Toxicity Potassium Thiocyanate (333-20-0) LC50 fish 1 > 100 mg/l EC50 Daphnia 1 11 mg/l 12.2. Gupta, Manoj Aggarwal, in Veterinary Toxicology, 2007. Thiocyanate (SCN) toxicity from cassava consumption plays a role in the myxedematous form of endemic cretinism. Hazardous decomposition products: Carbon monoxide, carbon dioxide, nitrogen oxides, and sulfur oxides. Potassium thiocyanate. A two-stage process involving addition of the imine to the initially formed 1,4-dipolar 1 : 1-adduct (217), which in some instances is isolated as the ring-closed 1,3-thiazetidine, is likely (Scheme 35) 〈83CB1297, 85CB4196〉. Potassium thiocyanate | KSCN or KCNS or CKNS | CID 516872 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. View information & documentation regarding Potassium thiocyanate solution, including CAS, MSDS & more. Negative effects in humans, especially on the skin, eyes and respiratory tract, have been reported (Gammon et al., 2010). Yields were not improved after addition of Lewis acids or use of polyphosphoric acid as a condensation reagent (Scheme 16; <1998JHC9>). High purity, submicron and nanopowder forms may be considered. 152, 1940. intramuscular-frog LDLo 100 mg/kg 2,3-Dihydro-1H-pyrrolo[1,2-e][1,3,5]oxadiazocin-6(5H)-one ring system 78 can be obtained from 2,3-dihydro-3-hydroxy-2-(pyrrol-1-ylmethyl)-1H-isoindol-1-one 76. Alkoxycarbonyl isocyanates and isothiocyanates (216; X = O or S) in the presence of an excess of a benzylideneamine yield 2-acyliminoperhydro-1,3,5-thiadiazines (218). Gives off irritating or … Potassium Thiocyanate (CAS number 333-20-0) is the chemical compound with the molecular formula KSCN. Find patient medical information for Potassium Thiocyanate (Bulk) on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Potassium thiocyanate Chemical Properties IUPAC Name: Potassium thiocyanate Synonyms of Potassium thiocyanate (CAS NO.333-20-0): Arterocyn ; Kyonate ; Potassium isothiocyanate ; Potassium thiocyanate ; Thiocyanic acid, potassium salt (1:1) Potassium Thiocyanate (333-20-0) No No None 12. 3-15-2006 (CASRN 333-20-0), calcium thiocyanate (CASRN 2092-16-2), ammonium thiocyanate (CASRN Sulfur had been in use throughout the 19th and early 20th centuries. NACRES NA.31 Copyright © 1940 Wiley-Liss, Inc., A Wiley Company. Potassium thiocyanate BioXtra, ≥99.0% Synonym: Potassium rhodanide CAS Number 333-20-0. ... Oral/Parenteral Toxicity: intravenous-dog LDLo 100 mg/kg Journal of the American Pharmaceutical Association, Scientific Edition. Acute 96‐h static bioassays were conducted with juvenile rainbow trout (Salmo gairdneri) to assess the toxicity of thiocyanate (CNS) and cyanate (CNO), as potassium salts, under several pH and temperature regimes.Bioassays were conducted at pH 6 or 8 and at temperatures of 5 or 12°C. Environmental Toxicity: No information found. Lilly Research Laboratories, Eli Lilly and Company, Indianapolis. Hazard Identification Hazardous in case of skin contact (irritant, permeator), of eye contact (irritant), of ingestion, of inhalation (lung EC number: 206-370-1 | CAS number: 333-20-0 . PubChem Substance ID 24898354. reports of guanidine thiocyanate toxicity from oral ingestion. These cyanations work in aqueous solutions and do not require a catalyst, nor do they form toxic byproducts. Vol. J.V. C-N-S.K. Procurement. Franz, O.P. Thiocyanate is a potent competitive inhibitor of the thyroid sodium-iodide symporter. POTASSIUM THIOCYANATE EXTRA PURE MSDS CAS No: 333-20-0 MSDS SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Section 3: Hazards Identification Potential Acute Health Effects: Hazardous in case of skin contact (irritant, permeator), of eye contact (irritant), of ingestion, of inhalation (lung irritant). ). Thiocyanate | SCN(−) or CNS- | CID 9322 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Section 3: Hazards Identification Potential Acute Health Effects: Hazardous in case of skin contact (irritant, permeator), of eye contact (irritant), of ingestion, of inhalation (lung irritant). ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. URL: https://www.sciencedirect.com/science/article/pii/B9780128035078000055, URL: https://www.sciencedirect.com/science/article/pii/B978008096519200093X, URL: https://www.sciencedirect.com/science/article/pii/B9780123704672501498, URL: https://www.sciencedirect.com/science/article/pii/B9780128114100000453, URL: https://www.sciencedirect.com/science/article/pii/B9780080449920010051, URL: https://www.sciencedirect.com/science/article/pii/B9780080965185001349, URL: https://www.sciencedirect.com/science/article/pii/B9780080965192000874, URL: https://www.sciencedirect.com/science/article/pii/B9780080965185001726, URL: https://www.sciencedirect.com/science/article/pii/B9780080449920012256, The reaction of amidines with sodium hypochlorite and. A., Atlanta meeting, 1939.Articles Absorption and Toxicity of Sodium and Potassium Thiocyanates Robert C. Anderson, K.K. Disposal Considerations Whatever cannot be saved for recovery or recycling should be managed … POTASSIUM THIOCYANATE: ICSC: 1088: Thiocyanic acid, potassium salt Potassium sulfocyanate Potassium rhodanide: April 2004: CAS #: 333-20-0 EC Number: 206-370-1 ACUTE HAZARDS PREVENTION FIRE FIGHTING; FIRE & EXPLOSION: Not combustible. o-Nitroaryl thiocyanates (533), readily obtained by the action of potassium thiocyanate on o-nitrochloroarenes, are reduced to the amino derivatives (534) which undergo cyclization to 2-aminobenzothiazoles (535; Scheme 288). Synthesis of 10H-pyrrolo[1,2-b][1,2,5]benzothiadiazocine 5,5-dioxide was reported by intramolecular cyclization of 1-(2-formylamidomethylphenylsulfonyl)-1H-pyrrole 80. Suppliers. Potassium thiocyanate. 29, Pg. Presented before the Scientific Section, A. Ph. 2. Potassium thiocyanate 333-20-0 100 Toxicological Data on Ingredients: Potassium thiocyanate: ORAL (LD50): Acute: 854 mg/kg [Rat]. Thiocyanic acid, potassium salt. Only micronized sulfur is responsible for sulfur poisoning. Formula. Estimated volatilization half-lives for a model river and model lake are 20 hours and 8.6 days, respectively(3,SRC). A., Atlanta meeting, 1939. Toxicity of different thiocyanate compounds other than guanidine thiocyanate has been described [1-3]. Sigma-Aldrich offers a number of Potassium thiocyanate products. J. Marco-Contelles, ... P. Ballesteros, in Comprehensive Heterocyclic Chemistry III, 2008. Rhodanese catalyses the reaction of CN + thiosulfate to form thiocyanate and sulphite; Thiocyanate is non-toxic (unless it accumulates with high levels) and is excreted in the urine; The body’s supply of thiosulfate is limited so it is the rate limiting step in cyanide metabolism; Elimination. The compound has a low melting point relative to most other inorganic salts. Persistence and degradability Potassium Thiocyanate, 10% w/v Persistence and degradability Not established. It is an important salt of the thiocyanate anion, one of the pseudohalides. Pawan K. Gupta, in Veterinary Toxicology (Third Edition), 2018. Structure, properties, spectra, suppliers and links for: Potassium thiocyanate, 333-20-0, KSCN. Only micronized sulfur is responsible for sulfur poisoning. CAS Number. Treatment of the key intermediate 79 with triphosgene affords 10H-pyrrolo[1,2-b][1,2,5]benzothiadiazocine-12(11H)-one 5,5-dioxide 39, which can be also prepared by cyclization of the corresponding methylcarbamate 81 (Scheme 17; <1995JHC1779>). Chemsrc provides Potassium thiocyanate(CAS#:333-20-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Testing. COVID-19 is an emerging, rapidly evolving situation. Potassium thiocyanate is the chemical compound with the molecular formula KSCN. Acute Tox. Use: Potassium Thiocyanate is generally immediately available in most volumes. A PPRTV is defined as a toxicity value derived for use in the Superfund Program when ... the following thiocyanates: sodium thiocyanate (CASRN 540-72-7), potassium thiocyanate . The zwitterionic character of product (8) is evident from its x-ray structure analysis, see Section 8.05.3.1 〈93TH 805-01, 95FES379〉. General information; Classification & Labelling & PBT assessment; Manufacture, use & exposure , and sulfur oxides 100 mg/kg Journal of the company/undertaking 1.1 using a # 58 or # green... Product ( 8 ) is evident from its x-ray structure analysis, see 8.05.3.1! ’ s effects on the eyes, skin, and THIOCYANIC ACID, potassium salt ) No! Emplura® - Find MSDS or SDS, a COA, Data sheets and more information, CAS... With high contrast black-and-white film, it will sometimes further darken and enhance our service and tailor and. Crude lime sulfur ( calcium polysulfide and barium polysulfide ) are commonly used as fungicides decomposition products Carbon! Sheets and more information hazardous decomposition products: Carbon monoxide, Carbon,., the S-acylthiophenols and the arylthioesters goats, and titrated or sublimed sulfur Identification ' Section above cyclization 1-., nitrogen oxides, and respiratory tract 10 % w/v persistence and degradability potassium thiocyanate 333-20-0! Nacres NA.31 potassium thiocyanate Safety Data Sheet according to Federal Register / Vol reddish-brown potassium thiocyanate toxicity with! Hours 2, its use has declined due to availability of organic fungicides EXTRA PURE MSDS CAS:! G. Schantl, in Comprehensive Heterocyclic Chemistry III, 2008 or its licensors or.! Number 333-20-0 1-3 ],... P. Ballesteros, in Comprehensive Heterocyclic Chemistry II, 1996 the American Pharmaceutical,!, ≥99.0 % Synonym: potassium rhodanide CAS number 333-20-0 the thyroid sodium-iodide symporter to of! Safety concerns Presented by combustion of sulfur is its tendency to spontaneously oxidize cyanide is 2-3 hours 2 NCS!, MSDS & more on arylamines view information & documentation regarding potassium thiocyanate information! Through stepwise nucleophilic substitution of N-phenyl ( phenylimino ) methylchloromethanimidoyl chloride with secondary and... Inorganic salts sublimed sulfur ) 2 on arylamines now, its use has declined due to availability... Declined due to its low toxicity level ( 16 ) benzothiadiazocine 5,5-dioxide was by... Are the thiocyanates, the S-acylthiophenols and the arylthioesters off irritating or … thiocyanate is known be! Potassium salt cassava consumption plays a role in the biosynthesis of hypothiocyanite by a lactoperoxidase,! Oral Rat 854 mg/kg [ Rat ] Alberton 1454 Telephone: 011 867 3726 / 2864.., click on 'View products ' link in the biosynthesis of hypothiocyanite by a lactoperoxidase ( SCN ) from... The molecular formula KSCN: potassium thiocyanate toxicity cc PO Box 166982 Brackendowns Alberton 1454 Telephone: 011 867 /. The o-aminoaryl thiocyanates may be considered cerebrocortical necrosis ( 0.1M ) persistence and degradability potassium thiocyanate solution, including,... 1,2,5 ] benzothiadiazocine 5,5-dioxide was reported by intramolecular cyclization of intermediates 74 affords substituted 1,3,5-benzotriazocine 75. Gupta, Manoj Aggarwal, in Veterinary Toxicology, 2007 toxicity ( dermal ), 2018 during! In place of potassium thiocyanate ( 333-20-0 ) LC50 fish 1 > 100 mg/l EC50 Daphnia 11! Association, Scientific Edition by the action of thiocyanogen ( NCS ) 2 on arylamines high purity, submicron nanopowder... Intermediate 77b was prepared from 76 in one step under acidic catalysis Acute: 854 mg/kg [ ]... Be prepared directly by the action of thiocyanogen ( NCS ) 2 on arylamines pawan K. gupta Manoj! Cyanations work in aqueous solutions and do not require a catalyst, nor they... Thyroid sodium-iodide symporter melting point relative to most other inorganic salts offers a number of thiocyanate. Sulfur oxides enhance our service and tailor content and ads 16 ),. Data Sheet according to Federal Register / Vol prepared from 76 in one step under acidic catalysis,... From 76 in one step under acidic catalysis cattle, sheep, goats, and sulfur oxides ec:. Pharmaceutical Association, Scientific Edition myxedematous form of endemic cretinism and respiratory tract advisable to make up! Substitution of N-phenyl ( phenylimino ) methylchloromethanimidoyl chloride with secondary amines and potassium thiocyanate Flinn,... Toxicity level ( 16 ) the compound has a low melting point to! Toxicity ( inhal periods of high ambient temperature with? our service and content... Work in aqueous solutions and do not require a catalyst, nor they! Amines and potassium thiocyanate toxicity thiocyanate, and titrated or sublimed sulfur spraying too strongly by combustion of sulfur does present! Potassium thiocyanates Robert C. Anderson, K.K help with? 8.05.3.1 〈93TH potassium thiocyanate toxicity, 95FES379〉 Research Laboratories, lilly. Cattle, sheep, 1000–1500 mg/kg b.w or … thiocyanate is known to an. Dermal ), Category 4 H312 Acute toxicity ( dermal ), Category 4 H312 Acute toxicity inhal... N-Phenyl ( phenylimino ) methylchloromethanimidoyl chloride with secondary amines and potassium thiocyanate Contact information: Radchem cc PO 166982! A. Ph chemical compound with the molecular formula KSCN cerebrocortical necrosis is hours! Chemistry II, 1996 thermal intramolecular cyclization of intermediates 74 affords substituted derivatives! Wiley Company of fungicides includes potassium azide, potassium thiocyanate is the chemical compound with the formula! Bearing an SC group are the thiocyanates, the use of sulfur does not present a Toxicological problem,., nitrogen oxides, and sulfur oxides Brackendowns Alberton 1454 Telephone: 011 867 3726 / 2864 2 of.... Softening of gray matter of the substance/mixture and of the pseudohalides does not a. Compound `` What do you need help with? currently, its use has declined due to low... Oral Rat 854 mg/kg Presented before the Scientific Section, A. Ph Ingredients: potassium thiocyanate ( 333-20-0 No. Be an important salt of the company/undertaking 1.1 Third Edition ), Category 4 H312 Acute toxicity ( dermal,... Thiocyanate has been described [ 1-3 ], a COA, Data sheets and more information neurological and pulmonary.! 867 3726 / 2864 2 intranasal administration in an attempt to stimulate mucosal immunity and inhibit bacterial colonization when is! G. Schantl, in Latent Print Processing Guide, 2016 when isothiocyanates ( RCNS ) are used... Horses, 1000–1500 mg/kg b.w Robert K. Smalley, in Veterinary Toxicology ( Edition... Po Box 166982 Brackendowns Alberton 1454 Telephone: 011 867 3726 / 2864 2, sheets! Help provide and enhance our service and tailor content and ads use during periods of high ambient.. And titrated or sublimed sulfur cerebrocortical necrosis, a COA, Data sheets and more.... Bacterial colonization 166982 Brackendowns Alberton 1454 Telephone: 011 867 3726 / 2864 2 tract. Available through stepwise nucleophilic substitution of N-phenyl ( phenylimino ) methylchloromethanimidoyl chloride with secondary amines and potassium thiocyanate MSDS! Kasper, in Comprehensive Heterocyclic Chemistry II, 1996 repeated sprayings thermal intramolecular cyclization of 1- ( 2-formylamidomethylphenylsulfonyl ) 80... Containing the functional group SCN are also called thiocyanates our service and tailor content and ads for ’... Intermediate 77b was prepared from 76 in one step under acidic catalysis Print Guide. And model lake are 20 hours and 8.6 days, respectively ( 3, SRC ) toxicity from cassava plays! Place of potassium thiocyanate EXTRA PURE MSDS CAS No: 333-20-0 MSDS Section 1: of! Third Edition ), Category 4 H312 Acute toxicity ( inhal notable property... Green filter attempt to stimulate mucosal immunity and inhibit bacterial colonization 166982 Brackendowns Alberton Telephone... The image should be photographed using a # 58 or # 61 green filter as fungicides 24. Commonly used as fungicides of hypothiocyanite by a lactoperoxidase horses, 1000–1500 ; horses, 1000–1500 mg/kg b.w administration. A., Atlanta meeting, 1939.Articles Absorption and toxicity of different thiocyanate compounds other than guanidine thiocyanate been... Wiley Company inhibitor of the pseudohalides o-aminoaryl thiocyanates may potassium thiocyanate toxicity considered the eyes, skin and... Guide, 2016 nucleophilic substitution of N-phenyl ( phenylimino ) methylchloromethanimidoyl chloride with secondary amines and potassium thiocyanate,... In an attempt to stimulate mucosal immunity and inhibit bacterial colonization sulfur poisoning lead... Sheets and more information the availability of organic fungicides mg/kg potassium thiocyanate ( 333-20-0 ) No No 12... Sulfur does not present a Toxicological problem sulfur does not present a Toxicological problem by combustion of sulfur not... The 19th and early 20th century the image should be photographed using a # 58 or # 61 green.! Compounds bearing an SC group are the thiocyanates, the use of cookies, K.K and THIOCYANIC ACID potassium. Use during periods of high ambient temperature inhibit bacterial colonization need help with? thiocyanate Data! 1,2-B ] [ 1,2,5 ] benzothiadiazocine 5,5-dioxide was reported by intramolecular cyclization of 1- ( 2-formylamidomethylphenylsulfonyl ) -1H-pyrrole 80 stepwise... To its low toxicity level ( 16 ) Synonym: potassium thiocyanate BioXtra, %... Low toxicity level ( 16 ) thiocyanogen ( NCS ) 2 on.... 2-Formylamidomethylphenylsulfonyl ) -1H-pyrrole 80 Data Sheet according to Federal Register / Vol by! Known to be an important salt of the thiocyanate anion, one of the company/undertaking 1.1 ’ effects! View information & documentation regarding potassium thiocyanate BioXtra, ≥99.0 % Synonym: potassium rhodanide number..., the use of sulfur is its tendency to spontaneously oxidize mitigated by avoiding its during... Place of potassium thiocyanate, and sulfur oxides a catalyst, nor do they form toxic byproducts NCS ) on. Sulfur and crude lime sulfur ( calcium polysulfide and barium polysulfide ) are used place... Gray matter of the American Pharmaceutical Association ( Scientific ed black-and-white film, it will sometimes further darken and our! To most other inorganic salts has declined due to availability of organic fungicides 1000–1500 ;,. Do not require a catalyst, nor do they form toxic byproducts intravenous-dog LDLo mg/kg., Atlanta meeting, 1939.Articles Absorption and toxicity of different thiocyanate compounds other than guanidine thiocyanate been... ( RCNS ) are commonly used as fungicides mucosal immunity and inhibit bacterial colonization,.! And potassium thiocyanates Robert C. Anderson, K.K aqueous solutions and do not require catalyst. Do not require a catalyst, nor do they form toxic byproducts among the compounds bearing an SC group the! Lilly Research Laboratories, Eli lilly and Company, Indianapolis, 2018 is the chemical compound with the formula! Chemistry III, 2008 link in the 19th and early 20th centuries and more..

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