chloramphenicol side effects in pregnancy

This study is the first to investigate potential foetal risks associated with topical chloramphenicol during pregnancy. phenobarbital, rifampicin) may decrease chloramphenicol plasma concentrations. You may report side effects to the FDA at 1-800-FDA-1088. There are no controlled data in human pregnancy. Few antibiotic agents have been proved to be teratogenic. Chloramphenicol : Therapeutic uses, Dosage & Side Effects Chloramphenicol is an broad spectrum antibiotic. By continuing to browse this site, you agree to its use of cookies as described in our, I have read and accept the Wiley Online Library Terms and Conditions of Use, The Danish national Hospital register. 1999). Portions of this document last updated: Feb. 01, 2020 Learn how to use Chloramphenicol, and it's dosage, warnings, side-effects, and more. If the mother must receive this drug during nursing, the infant should be monitored (gastrointestinal disturbances, adequacy of breastfeeding, complete blood count and differential); discontinuation of nursing may be preferred in some cases.WHO: Use should be avoided if possible, especially in infants younger than 1 month; infants should be monitored for side effects (hemolysis, jaundice).-According to some authorities: Use is contraindicated.-According to some authorities: Use is not recommended.-According to some authorities: A decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother.Excreted into human milk: YesComments:-Adverse effects (e.g., falling asleep at the breast, excessive intestinal gas, vomiting) have been noted in nursing infants whose mothers were taking oral chloramphenicol.-There is a theoretic risk of idiosyncratic bone marrow suppression and grey syndrome in the infant.-Use of this drug during breastfeeding is considered to be of concern by the American Academy of Pediatrics; according to some experts, this drug should be avoided. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Chloramphenicol is absorbed systemically from the eye, and toxicity has been reported following chronic exposure. Learn more about Chloramphenicol Chloramphenicol Injection: learn about side effects, dosage, special precautions, ... plan to become pregnant, or are breast-feeding. Information on births was collected from the Danish Medical Birth Registry (Knudsen & Olsen 1998), and information on drug redemption was gathered from the Danish National Prescription Registry (Kildemoes et al. But the side effects of chloramphenicol are not negligible. 966 372 births between 1997 and 2011 were included. 2011; Lupattelli et al. Common side effects of chloramphenicol include: not enough red blood cells produced (aplastic anemia) Chloramphenicol may cause gray baby syndrome, a serious and often fatal reaction to the drug. The rate of exposed women was lower during pregnancy as compared to 3 months before and after pregnancy (p < 0.0001) (Fig. All infants had excessive intestinal gas and abdominal distention; severe problems occurred in 0.5%, 20%, and 100% of infants with daily maternal doses of 1, 2, and 3 g, respectively. 1982). It was initially isolated from the bacteria Streptomyces venezuelae in 1948 and was the first bulk produced synthetic antibiotic. The authors conducted a nationwide cohort study including all women giving live birth between 1997 and 2011 in Denmark. Peak milk level averaged 3.24 mg/L (range: 2.5 to 4.5 mg/L) and occurred 2 hours after dosing; by 8 hours after dosing, milk level averaged 0.31 mg/L. 4.8 Undesirable effects Blood dyscrasias have been reported in association with the use of chloramphenicol (see Warnings and Precautions). 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